Longidaza Impact on Artificially Induced Spinal Cord Epidural Fibrosis in Rat
DOI:
https://doi.org/10.29038/2617-4723-2016-332-7-159-164Keywords:
fibrosis, соеденительная fabric, longidazaAbstract
Longidaza at dose 1ml/kg impact on artificially induced epidural fibrosis in spinal cord of the wistar rat was investigated. It was shown that administration of chosen concentration of a drug leads to fibrosis structures quantity decrease. Wherein proportion between neural and connective tissue after induction of fibrosis and drug application reduced on 23 % during 5 days and 38 % after 10 days. Maximum fibrosis thickness decline accordingly on 31 % and 43 %. The most significant changes was in decrease of the fibrosis area, up to 56 % after 5 days of the experiment and 78 after 10 days. Results show that longidaza is effectively influences measure of pathological alteration of spinal cord tissues during epidural fibrosis. Due to longidaza administration not only pathologicaly affected area is diminish but also scar tissue itself became less dense and thick. Because of the destructiveness of used fibrosis induction methods in experiment we can suggest that probably it is possible almostly prevent fibrosis using longidaza during minor traumas of spinal cord and surrounding tissues.
References
2. Riordan J. R. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA / J. R. Riordan, J. M. Rommens, B. Kerem [et al.] // Science. – 1989. – Vol. 245. – P. 1066–1073.
3. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases / G. Gabbiani // J. Pathol. – 2003. – P. 500–503.
4. Eckes B. Fibroblast-matrix interactions in wound healing and fibrosis / B. Eckes, P. Zigrino, D. Kessler // Matrix Biol. – 2000. – Vol. 19. – P. 325–332.
5. Шуваева О. Б. Клинический полиморфизм рецидивирующих болевых синдромов после оперативного вмешательства при компрессионной радикулопатии на пояснично-крестцовом уровне / О. Б. Шуваева // Журнал неврологии и психиатрии. – 2005. – № 11. – С. 11–15.
6. Ross J. S. The postoperative lumbar spine: evaluation of epidural scar over a 1-year period / J. S. Ross, N. Obuchowski, R. Zepp // AJNR Am J Neuroradiol. – 1998. – № 19. – Р. 183–186.
7. Leena James. Management of Oral Submucous Fibrosis with Injection of Hyaluronidase and Dexamethasone in Grade III Oral Submucous Fibrosis: A Retrospective Study / James Leena, Shetty Akshay, Rishi Diljith, Abraham Marin // J Int Oral Health. – 2015. – № 7. – Р. 82–85.
8. Баринов А. Н. Лечение невропатической боли / А. Н. Баринов, Н. Н. Яхно // РМЖ. Т. – 2003. – 11. – № 25. – С. 1419–1422.
9. Герасимова М. М. Цитомедины в комплексной терапии пояснично-крестцовых радикулопатий / М. М. Ге-расимова. – СПб. : Наука. 2005. – С. 114–122.
10. Жулев Н. М. Остеохондроз позвоночника / Н. М. Жулев, Ю. Д. Бадзгарадзе, С. Н. Жулев. – СПб. : Лань, 2001. – 592 с.
11. Dyakonova V. A. Study of interaction between the polyoxidonium immunomodulator and the human immune system cells / V. A. Dyakonova, V. A. Dambaeva, S. V. Dambaeva, R. M. Khaitov // Int. Immunopharmacol. – 2004. – Vol. 15. – № 13. – P. 1615–1623.
12. Коржевский Д. Э. Краткое изложение основ гистологической техники для врачей и лаборантов-гистологов / Д. Э. Коржевский. – СПб., 2005. – 47 с.
