Features of the content of pro-inflammatory cytokins in chronic heart failure
Keywords:cytokines, immune cells, immune-inflammatory reaction, ischemic heart disease, arterial hypertension, chronic heart failure
Various endogenous mechanisms are involved in the development and progression of chronic heart failure (CHF). The aim of the study was to study the content of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), in patients with CHF. The study included 149 patients with CHF, aged 18 to 75 years, who were receiving inpatient treatment in the heart failure department of the National Center for Cardiology "Institute of Cardiology named after Acad. M.D. Strazheska" of the National Academy of Sciences of Ukraine during 2020-2022. TNF-α and IL-6 were determined in blood serum and supernatants by the enzyme-linked immunosorbent assay method. An increase (p ≤ 0.05) in the levels of TNF-α and IL-6 in the blood serum of patients with CHF was demonstrated. A higher level of studied cytokines was observed in patients with atrial fibrillation compared to patients with sinus rhythm. The levels of TNF-α and IL-6 increased with increasing of functional class. The highest levels were observed in patients with left ventricular ejection fraction ≤ 25% and 26-35% compared to the group of patients with left ventricular ejection fraction ≥ 36%. Also, the level of these pro-inflammatory cytokines increased with the age of the disease. Depending on the diagnosis, the highest level of TNF-α was observed in patients with dilated cardiomyopathy, and the lowest (at the control level) in patients with coronary heart disease without hypertensive disease. At the same time, the levels of IL-6 in the blood of these patients are opposite - the lowest level is observed in patients with dilated cardiomyopathy, and the highest level is observed in patients with coronary heart disease without hypertensive disease. Also, an increase (p ≤ 0.05) in the cytokine-producing capacity of the peripheral blood mononuclear cells of patients with CHF, both spontaneous and induced, was shown. At the same time, changes in the values of the studied indicators in different subgroups were similar to changes in the content of cytokines in the blood of patients. It was established that the immune-inflammatory activation of immunocompetent cells was enhanced in all patients with CHF.
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