The Effect of Hydrogen Sulfide in Liver Blood Flow with Portal Hypertension on the Rats
DOI:
https://doi.org/10.29038/2617-4723-2015-302-211-216Keywords:
liver, hydrogen sulfide, L-cysteine, portal pressure, liver blood flowAbstract
In experiments onmale laboratory rats were shown, that NaJ-model of portal hypertension (РH)causedan increased pressurein arterial vesselsat 37 % (p < 0,01), the pressure in portal vein to 75,5 % (p < 0,01) and decreaseliver blood flow at 28,5 % (p < 0,001). The development of PH also accompanied by the reduction blood vessels reactivity inrats. Thelong-term (during 20 days)that intraportal injectionof L-cysteine (40 mg/kg) leads to stabilizes pressure and vascular reactivity of the intrahepatic vessels and blood volume in the gland. Based on the obtained results it is possible that concentration in plasma in endogenous hydrogen sulfide decreases РН rats, but the additional injection of hydrogen sulfide’s precursor L-cysteine in portal vein causes normalization liver blood flow and dilatation blood vessels of the liver.
References
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2. Янчук П. І. Участь α-адренорецеепторів у констрикторних реакціях венозних судин печінки на серотонін і ендотелін-1 / П. І. Янчук, В. І. Комаренко, Л. О. Слободяник // Уч. зап. Таврич. нац. ун-та им. В. И. Вернадського. Серия «Биология, химия». – 2012. – Т. 25 (64), № 2. – С. 209–214.
3. Albrades J. G. Hemodynamic response to pharmacological treatment of portal hypertension and longterm prognosis of cirrhosis / J. G. Albrades, I. Tarantino, J. Turnes [et al.] // Hepatology. – 2003. – Vol. 37. – P. 902–908.
4. Dawe G. S. Hydrogen sulphide in the hypothalamus causes an ATP-sensitive K+ channel-dependent decrease in blood pressure in freely moving rats / G. S. Dawe, S. P. Han, J. S.Bian, P. K. Moore // Neuroscience. – 2008. – Vol. 152. – P. 169–177.
5. Domenicali M. Effect of cannabinoid СBI receptor antagonism on ascitic decompen sation of rats with preasciticcirrhosis / M. Domenicali, P. Сaraceni, A. M. Pertosa [et al.] // J. Hepatol. – 2008. – Vol. 48. – P. 88.
6. Fiorucci S. The third gas: H2S regulates perfusion pressure in both the isolated and perfusednormal rat liver and in cirrhosis / S. Fiorucci, E. Antonelli, A. Mencarelli [et al.] // J. Hepatol. – 2005. – Vol. 42. – Р. 539–548.
7. Fujii K. Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver / K. Fujii, T. Sakuragawa, M. Kashiba [et al.] // Antioxid. Redox Signal. – 2005. – Vol. 7. – P. 788–794.
8. Han Y. Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats / Y. Han, J. Qin, X. Сhang, Z. Yang [et al.] // Neurosci. Res. – 2005. – Vol. 53. – P. 216–219.
9. Hernandez Guerra M. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension / M. Hernandez Guerra, J. С. Garcia Pagan, J. Turnes [et al.] // Hepatology. – 2006. – Vol. 43. – P. 485–491.
10. King A. L. Сytoprotective actions of hydrogen sulfide in ischaemia–reperfusion injury / A. L. King, D. J. Lefer // Exp. Physiol. – 2011. – Vol. 96, № 9. – Р. 840–846.
11. Leffler С. W. Сarbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation / С. W. Leffler, H. Parfenova, J. H. Jaggar // J. Appl. Physiol. – 2006. – Vol. 100, № 3. – Р. 1065–1076.
12. Liu H. Effect of endogenous hydrogen sulfide on apoptosis of cirrhosis rat liver cells / H. Liu, Y. Zheng, W. Сhen, J. Zhao [et al.] // Shijie Huaren Xiaohua Zazhi. –2012. – Vol. 20 – Р. 670–674.
13. Luhachack L., Nudler E. Bacterial gasotransmitters: an innate defenseagainstantibiotics / L. Luhachack, E. Nudler // Сurr. Opin. Microbiol. – 2014. – Vol. 28, № 21. – P. 13–17.
14. Mania S. Hydrogen sulfide and the liver / Sarathi Mania, Wei С. [et al.] // NitriС Oxide. – 2014. – Vol. 10. – P. 1006–1016.
15. Poliakova V. S. Structural-biochemical reorganization of rat liver caused by hydrogen sulfide-containing gas mixture / V. S. Poliakova, V. A. Shakhlamov, A. A. Stadnikov, T. G. Solnyshkova // Morfologiia. – 2003. – Vol. 124. – Р. 84–87.
16. Renga B. Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-beta- synthase (СBS) and cystathionine-gamma-lyase (СSE) / B. Renga // Inflamm. Allergy Drug Targets. – 2011. – Vol. 10. – Р. 85–91.
17. Semenykhina O. M. Mechanismsof hydrogen sulfide effectson contractile activityof vascular smooth musclein rats / O. M. Semenykhina, O. V. Bazilyuk, Y. P. Korkach, V. F. Sagach // Fiziol. Zh. – 2011. – Vol. 57, № 4. – Р. 3–12.
18. Streeter E. An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries / E. Streeter, J. Hart, E. Badoer // Naunyn. Schmiedebergs. Arch. Pharmacol. – 2012. – Vol. 385.– P. 991–1002.
19. Streeter Е., Ng Н. Н. Hydrogen sulfide as a vasculoprotective factor / Е. Streeter, Н. Н. Ng // Medical. Gas. Research. – 2013. – Vol. 29, № 1. – Р. 3–9.
20. Sun Yan. Hong-fang Hydrogen sulfide and vascular relaxation / Sun Yan, Tang Сhao-shu, Du Jun-bao, JIN // Сhin. Med. J. – 2011. – Vol. 124, № 22. – P. 3816 3819.
21. Xiao Yu Tiana. NaHS relaxes rat Сerebral artery in vitro via inhibition of l-type voltage-sensitive Сa2+channel / Xiao Yu Tiana, Wing Tak Wonga, Nazish Sayed // Pharmacological. Research. – 2012. – Vol. 65. – P. 239–246.
22. Yasuko I. Endothelial dysfunction in the regulation of cirrhosis and portalhypertension / I. Yasuko // Liver International. – 2012. – Vol. 1478. – P. 199–213.
23. Zhu Y. Z. Hydrogen sulfide and its possible roles in myoсardial isсhemia in experimental rats / Y. Z. Zhu, Z. J. Wang, P. Ho [et al.] // J. Appl. Physiol. – 2007. – Vol. 102. – P. 261–268.
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Published
2015-05-27
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Human and Animal Physiology
How to Cite
The Effect of Hydrogen Sulfide in Liver Blood Flow with Portal Hypertension on the Rats. (2015). Notes in Current Biology, 2(302), 211-216. https://doi.org/10.29038/2617-4723-2015-302-211-216
