COVID-19 and its consequences for the emotional and volitional sphere elderly and senile persons

Authors

DOI:

https://doi.org/10.29038/NCBio.24.1-7

Keywords:

the epidemic of COVID-19, postcovid, an infectious disease, stress, post-traumatic stress disorder.

Abstract

The presence of a variety of symptoms that last longer than the acute phase of COVID-19 is called post-COVID syndrome (PCS). Musculoskeletal, digestive (i.e., diarrhea), and neurological symptoms, including depression (according to the Zung scale), were most commonly observed in patients with PCS. Fatigue/muscle weakness, dyspnea, pain and discomfort, anxiety/depression, and impaired concentration were observed in more than 20% of patients. PCS is mainly characterized by musculoskeletal, lung, digestive and neurological disorders, including depression. PCS is independent of the severity of the acute illness and the humoral response. During and after infection with COVID-19, patients are at increased risk of developing depression and anxiety.

Many people with COVID-19 are at risk of long-term impairment and disability, especially in critical cases. Symptoms after acute COVID-19 are highly variable and varied. Not only the stressors associated with the consequences of the infection of COVID-19, but also the measures taken against the pandemic can lead to the development of new mental illnesses or the worsening of existing mental health disorders. Depressive disorders affect physical, mental, and social functioning and increase the risk of premature death. People who survived COVID-19 had a high prevalence of acute psychiatric complications. Common neuropsychiatric sequelae following SARS-CoV-2 infection included fatigue, sleep problems, anxiety, depression, post-traumatic stress disorder, headache, raving, and cognitive impairment. Additional diverse manifestations of COVID-19 have been noted, such as delirium, peripheral neuropathy, dizziness, and mood disorders.

References

Anaya J. M., Rojas M, Salinas M. L., Rodríguez Y, Roa G, Lozano M, Rodríguez-Jiménez M, Montoya N, Zapata E; Post-COVID study group; Monsalve DM, Acosta-Ampudia Y, Ramírez-Santana C. Post-COVID syndrome. A case series and comprehensive review. Autoimmun Rev. 2021 Nov;20(11):102947. doi: 10.1016/j.autrev.2021.102947. Epub 2021 Sep 10. PMID: 34509649; PMCID: PMC8428988.

Nakamura Z. M., Nash R. P., Laughon S.L., Rosenstein D.L. Neuropsychiatric Complications of COVID-19. Curr Psychiatry Rep. 2021 Mar 16. 23(5). 25. doi: 10.1007/s11920-021-01237-9. PMID: 33725218; PMCID: PMC7962429.

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA2020; 323: 1239-1242.

Ciotti M, Angeletti S, Minieri M, Giovannetti M, Benvenuto D, Pascarella S, Sagnelli C, Bianchi M, Bernardini S, Ciccozzi M. COVID-19 Outbreak: An Overview. Chemotherapy. 2019;64(5-6):215-223.

WHO Coronavirus (COVID-19) Dashboard. URL: https://covid19.who.int/?gclid=Cj0KCQjw84anBhCtARIsAISI-xeH96URVn2G8mLYI7YeKt2VN6oaQ5Y522VjEYiRifTKZsQvSUCherAaAsSBEALw_wcB (data zvernennia: 13.07.2023).

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 Feb;323(11):1061.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al.; China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Feb;382(8):727–733.

Bai Y, Wei LYT, Tian F, Jin D-Y, Chen L, Wang M. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020.

Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: estimation and Application. Ann Intern Med. 2020.

Backer JA, Klinkenberg D, Wallinga J. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020. Euro Surveill. 2020 Feb;25((5)).

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020 Jan;:NEJMoa2001316.

Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020 Jan;25((3)):2000045.

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020 Feb;395((10224)):565–74.

NICE: COVID-19 Rapid Guideline: Managing the Longterm Effects of COVID-19. URL: https://www.nice.org. uk/guidance/ng188/resources/covid19-rapid-guideline-managing-the-longterm-effects-of-covid19-pdf-51035515742

Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012 Nov;367((19)):1814–20.

Review article: Hematologic Abnormalities Associated with Post-Acute COVID-19 Sequelae or “long-COVID”- a Systematic Review Jamie-lee Brundyn, Jamie Gillan, Indu Singh Int. J. Bio. Lab. Sci 2022(11)1:23-42.

Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., Kang L., Guo L., Liu M., Zhou X., Luo J., Huang Z., Tu S., Zhao Y., Chen L., Xu D., Li Y., Li C., Peng L., Li Y., Xie W., Cui D., Shang L., Fan G., Xu J., Wang G., Wang Y., Zhong J., Wang C., Wang J., Zhang D., Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021 Jan 16. 397(10270). 220-232. doi: 10.1016/S0140-6736(20)32656-8. Epub 2021 Jan 8. PMID: 33428867; PMCID: PMC7833295.

Rodriguez-Morales A.J., Cardona-Ospina J.A., Gutiérrez-Ocampo E., Villamizar-Peña R., Holguin-Rivera Y., Escalera-Antezana J.P., Alvarado-Arnez L.E., Bonilla-Aldana D.K., Franco-Paredes C., Henao-Martinez A.F., Paniz-Mondolfi A., Lagos-Grisales G.J., Ramírez-Vallejo E., Suárez J.A., Zambrano L.I., Villamil-Gómez W.E., Balbin-Ramon G.J., Rabaan A.A., Harapan H., Dhama K., Nishiura H,. Kataoka H., Ahmad T., Sah R.; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid.org. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020 Mar-Apr. 34. 101623. doi: 10.1016/j.tmaid.2020.101623. Epub 2020 Mar 13. PMID: 32179124; PMCID: PMC7102608.

Albert K.M., Newhouse P.A. Estrogen, Stress, and Depression: Cognitive and Biological Interactions. Annu Rev Clin Psychol. 2019 May 7. 5. 399-423. doi: 10.1146/annurev-clinpsy-050718-095557. Epub 2019 Feb 20. PMID: 30786242; PMCID: PMC9673602.

Chuang H.J., Hsiao M.Y., Wang T.G., Liang H.W. A multi-disciplinary rehabilitation approach for people surviving severe COVID-19-a case series and literature review. J Formos Med Assoc. 2022 Dec. 121(12). 2408-2415. doi: 10.1016/j.jfma.2022.02.002. Epub 2022 Feb 14. PMID: 35216882; PMCID: PMC8841152.

COVID-19 rapid guideline: managing the long-term effects of COVID-19. London: National Institute for Health and Care Excellence (NICE). 2020 Dec 18. PMID: 33555768.

Mazza M.G., De Lorenzo R., Conte C., Poletti S., Vai B., Bollettini I., Melloni E.M.T., Furlan R., Ciceri F., Rovere-Querini P.; COVID-19 BioB Outpatient Clinic Study group; Benedetti F. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun. 2020 Oct. 89. 594-600. doi: 10.1016/j.bbi.2020.07.037. Epub 2020 Jul 30. PMID: 32738287; PMCID: PMC7390748.

Miskowiak K.W., Johnsen S., Sattler S.M., Nielsen S., Kunalan K., Rungby J., Lapperre T., Porsberg C.M. Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables. Eur Neuropsychopharmacol. 2021 May. 46. 39-48. doi: 10.1016/j.euroneuro.2021.03.019. Epub 2021 Mar 29. PMID: 33823427; PMCID: PMC8006192.

Hallek M., Adorjan K., Behrends U., Ertl G., Suttorp N., Lehmann C. Post-COVID Syndrome. Dtsch Arztebl Int. 2023 Jan 27;120(4):48-55. doi: 10.3238/arztebl.m2022.0409. PMID: 36633452; PMCID: PMC10060997.

Czaplicki A., Reich H., Hegerl U. Lockdown Measures Against the Spread of the COVID-19 Pandemic: Negative Effects for People Living With Depression. Front Psychol. 2022 Feb 4. 13. 789173. doi: 10.3389/fpsyg.2022.789173. PMID: 35185723; PMCID: PMC8854217.

Numbers K., Brodaty H. The effects of the COVID-19 pandemic on people with dementia. Nat Rev Neurol. 2021 Feb. 17(2). 69-70. doi: 10.1038/s41582-020-00450-z. PMID: 33408384; PMCID: PMC7786184.

Rogers J.P., Chesney E., Oliver D., Pollak T.A., McGuire P., Fusar-Poli P., Zandi M.S., Lewis G., David A.S. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry. 2020 Jul. 7(7). 611-627. doi: 10.1016/S2215-0366(20)30203-0. Epub 2020 May 18. PMID: 32437679; PMCID: PMC7234781.

Taquet M., Geddes J.R., Husain M., Luciano S., Harrison P.J. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry. 2021 May. 8(5). 416-427. doi: 10.1016/S2215-0366(21)00084-5. Epub 2021 Apr 6. PMID: 33836148; PMCID: PMC8023694.

Burdick K.E., Millett C.E. The impact of COVID-19 on cognition in severe cases highlights the need for comprehensive neuropsychological evaluations in all survivors. Neuropsychopharmacology. 2021 Dec. 46(13). 2225. doi: 10.1038/s41386-021-00995-7. Epub 2021 Mar 22. PMID: 33753883; PMCID: PMC7983959.

Goodwin V.A., Allan L., Bethel A., Cowley A., Cross J.L., Day J., Drummond A., Hall A.J., Howard M., Morley N., Thompson Coon J., Lamb S.E. Rehabilitation to enable recovery from COVID-19: a rapid systematic review. Physiotherapy. 2021 Jun. 111. 4-22. doi: 10.1016/j.physio.2021.01.007. Epub 2021 Feb 24. PMID: 33637294; PMCID: PMC7902208.

Published

2024-06-26

Issue

Section

Human and Animal Physiology

How to Cite

COVID-19 and its consequences for the emotional and volitional sphere elderly and senile persons. (2024). Notes in Current Biology, 7(1). https://doi.org/10.29038/NCBio.24.1-7