Central and peripheral nitric oxide metabolites and BDNF content in rats with alcohol dependence and under intranasal administration of sodium nitroprusside
Keywords:nitric oxide metabolites, BDNF, brain structures, alcohol dependence, sodium nitroprusside
The aim of the study was to investigate the possibility of correcting the nitric oxide (NO) and BDNF deficiency in alcohol dependent rats by intranasal administration of the NO donor sodium nitroprusside (SNP). Intranasal administration of SNP to rats with alcohol dependence was carried out at a dose 8 μg/kg body weight twice a day on the background of alcohol withdrawal for 3 days. Nitric oxide metabolites (nitrites, nitrates; NOx) and BDNF concentration were measured in the brain structures and serum. Chronic alcohol consumption leads to a decrease of NOx and BDNF content in brain structures and BDNF concentration in serum in rats under alcohol withdrawal. SNP restores NOx level in the brain and BDNF concentration in serum on the background of NOx level decrease in serum. Intranasal administration of SNP causes recovery of NO cerebral functions and BDNF level in serum impaired as a result of chronic alcoholization.
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