Influence of C60 fullerenes the mechanokinetics of the fatigue development in rats skeletal muscles caused by the cardioembolic insult peptides


  • Iryna Dmytruk Lesia Ukrainka Volyn National University



С60 fullerenes, cardioembolic stroke, peptides, m. soleus, muscle fatigue


The purpose of the study was to determine the effect of the peptides fraction of the cardioembolic stroke acute phase on the parameters of skeletal muscle contraction, and to find out therapeutic effect on the development of muscle dysfunction of water-soluble fullerene С60. Plasma samples were taken from healthy individuals and patients with cardioembolic ischemic stroke. Peptide injections were administered intravenously 2 hours before the start of the experiment. С60 fullerenes were administered one hour after peptide administration. The following experimental groups were identified: control, cardioembolic stroke (acute phase), cardioembolic stroke + С60 fullerene injections. Analysis of fatigue mechanograms showed a significant reduction in the time of muscle fatigue onset, muscle power and the maximum possible level of force generation during using peptides of the cardioembolic stroke acute phase. Therapeutic use of С60 fullerene injections significantly reduces the level of these pathologies and stabilizes the biomechanical parameters of muscle contraction. С60 fullerenes have been shown to be able to maintain active muscle within physiological limits throughout the contraction process. Thus, С60 fullerenes can be considered as potential agents capable of correcting pathological conditions of the muscular system.


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How to Cite

Dmytruk, I. (2021). Influence of C60 fullerenes the mechanokinetics of the fatigue development in rats skeletal muscles caused by the cardioembolic insult peptides. Notes in Current Biology, (1 (1), 102–107.



Human and Animal Physiology