Bile Secretion Liver Function in the Female Rats at Estrogen Receptor Tamoxifen Blockade Conditions

Authors

  • Oksana Borovets International University of Economics and Humanities named after academician Stepan Demianchuk
  • Volodymyr Bened’ International University of Economics and Humanities named after academician Stepan Demianchuk
  • Evdokiay Reshetnik Taras Shevchenko National University of Kyiv
  • Stanislav Veselsky Taras Shevchenko National University of Kyiv
  • Mykola Makarchuk Taras Shevchenko National University of Kyiv

DOI:

https://doi.org/10.29038/2617-4723-2016-332-7-194-199

Keywords:

bile, bile acids, liver, estrogen receptors, tamoxifen

Abstract

Influence of tamoxifen (57,2 mkg per 100 g of body weight) on secretion of bile and bile acids was studied in acute experiments in female rats. The concentration of bile acids (taurocholic acid, taurochenodeoxycholic and taurodeoxycholic acids, glycocholic acid, glycochenodeoxycholic and glycodeoxycholic acids, cholic acid, chenodeoxycholic and deoxycholic acids) were determine in six samples of bile using thin layer chromatography. Tamoxifen effects on nuclear estrogen receptors. Concentration decreasing of glycocholic acid (27,8–34,3 %, р < 0,01) and cholic acid were observed in female rats bile while such of taurocholic acid increased (16,8–30,7 % (р<0,05). Tamoxifen caused significant changes in the biotransformation and biosynthesis of bile acids in the liver of the experimental female animals, as reflected by changes in the ratio of trihydroxycholic and dihydroxycholic acids. Thus, tamoxifen influencing metabolism and transport of bile acids does not increase its lithogenic characteristics.

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Published

2016-05-23

How to Cite

Borovets, O., Bened’, V., Reshetnik, E., Veselsky, S., & Makarchuk, M. (2016). Bile Secretion Liver Function in the Female Rats at Estrogen Receptor Tamoxifen Blockade Conditions. Notes in Current Biology, (7(332), 194–199. https://doi.org/10.29038/2617-4723-2016-332-7-194-199