The Value of Genetic Systems AB0, Rh and Hp in Stress-induced Immunoreactivity Among Residents Living in the Areas Contaminated With Radionuclides
DOI:
https://doi.org/10.29038/2617-4723-2016-332-7-142-147Keywords:
genetic blood system, Chernobyl, stress, immunityAbstract
We studied the importance of immuno-genetic systems AB0, Rh and Hp in dynamics of immune system work among residents of the areas contaminated with radionuclides, under conditions of emotional stress. The impact of examinations on the natural resistance of students who arrived for studying from the IV radiation zone and also the efficiency of recovery were evaluated. We discovered a significant inhibition of T-cell immunity with the norm overrun among examined patients. Suppression intensity and effectiveness of restorative process are influenced by immunogenetic factors of blood, especially erythrocytic system AB0 and serum haptoglobin Hp. The most pressing is a combination of phenotypes 0(I) and B(III) in system AB0, negative phenotype «Rhesus» and haptoglobin phenotype Hp2-2. Protective trend is most pronounced in combination of phenotypes A(II), Rh + and Hp2-2.
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4. AB0 Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes / K. T. Wolofsky, K. Ayi, D. R. Branch [et al.] // PLoS Pathog. – 2012. – V. 8, № 10. – P. e1002942.
5. Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement / P. Avery, N. Barzilai, A. Benetos [et al.] // Curr. Vasc. Pharmacol. – 2014. – V.12. – P. 662–673.
6. Cellular immunity and telomere length correlate with cognitive dysfunction in clean-up workers of the chernobyl accident / D. A. Bazyka, K. N. Loganovsky, I. N. Ilyenko [et al.] // Clinical Neuropsychiatry – 2013. – V.10, № 6. – P. 280.
7. Cooling L. Blood Groups in Infection and Host Susceptibility / L. Cooling // Clin. Microbiol. Rev. – 2015. – V. 28, № 3. – P. 801–870.
8. Effect of ionizing radiation on development process of T-cell population lymphocytes in Chernobyl children / M. R. Sajjadieh, L. V. Sheikh, V. B. Kuznetsova [et al.] // Iran. J. Radiat. Res. – 2009. – V.7. – P.127–133.
9. Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release / M. Arredouani, P. Matthijs, E. Van Hoeyveld [et al.] // Immunology. – 2003. – V.108, № 2. – P. 144–151.
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11. Profiling of low molecular weight proteins in plasma from locally irradiated individuals / R. Nylund, E. Lemola, S. Hartwig [et al.] // J. Radiat. Res. – 2014. – V. 55, № 4. – P. 674–682.
12. Quaye I. K. Haptoglobin, inflammation and disease / I. K. Quaye // Trans. R. Soc. Trop. Med. Hyg. – 2008. – V.102, № 8. – P. 735–742.
13. Rizzo C. Possible role of ABO system in age-related diseases and longevity: a narrative review / C. Rizzo, C. Caruso, S. Vasto // Immunity & Ageing. – 2014. – V.11. – P. 16–23.
14. The challenges in moving from ageing to successful longevity / G. Kolovou, N. Barzilai, C. Caruso [et al.] // Curr. Vasc. Pharmacol. – 2014. – V.12. – P. 659–661.
15. The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes / T. Costacou, C. Rosano, H. Aizenstein [et al.] // Diabetes. – 2015. – V. 64. – P. 654–659.
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Published
2016-05-23
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Human and Animal Physiology
How to Cite
The Value of Genetic Systems AB0, Rh and Hp in Stress-induced Immunoreactivity Among Residents Living in the Areas Contaminated With Radionuclides. (2016). Notes in Current Biology, 7(332), 142-147. https://doi.org/10.29038/2617-4723-2016-332-7-142-147
