Research of Antidepressive Activity of Di-Na-Salt Of 2-(Pyridine-4-Iltio)Succinic AciD
DOI:
https://doi.org/10.29038/2617-4723-2015-302-189-193Keywords:
antidepressive activity, di-Na-salt of 2-(pyridine-4-iltio)succinic acid, Porsolt’s test, test»Hanging of mice for a tail»Abstract
Nowadays the number of patients suffering from depressive disturbance which need a medical correction was recently enlargedin the world. In this work antidepressive action of untoxic substance – di-Na-salt of 2-(pyridine-4-iltio)succinic acid was studied in Porsolt’s test and «Hanging of mice by a tail».
In the Porsolt’s testdi-Na-salt of 2-(pyridine-4-iltio)succinic acidin a dose of 120 mg/kg caused reliable decrease of passive swimming time in relation to control which comes nearer to a comparison preparation indicator – a known strong antidepressant «Velaksin». The tendency to its augmentation was observedin the analysis of the 1-st lag time.
The results received in the «Hanging of mice by a tail» test indicate even more appreciable antidepressive activity of di-Na-salt of 2-(pyridine-4-iltio)succinic acid. At introduction of substance in more effective dose (120 mg/kg) appreciable decrease of immobility time was observed in relation to control that is almost near to a standard indicator – «Velaksin».
Thus, di-Na-salt of 2-(pyridine-4-iltio)succinic acid can serve for creation of new untoxical pharmaceutical preparationson its basis.
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