Serotonin Effects on Conjugation and Hydroxylation of Bile Acid in the Rats Liver
DOI:
https://doi.org/10.29038/2617-4723-2015-302-124-127Keywords:
serotonin, liver, bile acid, cholates conjugation and hydroxylationAbstract
In acute experiments on male rats with cannulated bile duct it was revealed stimulating effect of serotonin on the conjugation of bile acids with taurine as well as with glycine.Ketanserin blockade of 5-HT2R leads to the inhibition cholates conjugation with taurine and glycine and eliminates serotonin stimulating effects on bile acid conjugations in rat liver. In the rat bile not were found significant variations of hydroxylation under the influence of serotonin as well as on the background in ketanserin blocking 5-HT2R.
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5. Effect of 5-HT7 receptor blockade on liver regeneration after 60–70 % partial hepatectomy / K. N. Tzirogiannis, K. T. Kourentzi, S. Zyg [et al.] // BMC Gastroenterology. – 2014. – 14: 201. doi:10.1186/s12876-014-0201-2.
6. Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice / Zhang J., Song S., Pang Q. [et al.] // Sci Rep. – 2015. – 5:8098. doi: 10.1038/srep08098.
7. Serotonin promotes tumor growth in human hepatocellular cancer / Soll C., Jang J. H., Riener M. O. [et al.] // Hepatology. – 2010. – Vol. 51, №4. – P. 1244–1254.
8. Serotonin protects mouse liver from cholestatic injuryby decreasing bile salt pool after bile duct ligation / Jang J.-H., Rickenbacher A., Humar B. [et al.] // Hepatology. – 2012. – Vol. 56, Issue 1. – P. 209–218.
9. Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover / Watanabe H., Akasaka D., Ogasawara H. [et al.] // Endocrinology. – 2010. – Vol. 151, № 10. – Р. 4776–4786.
10. Effect of peripheral 5-HT on glucose and lipid metabolism in wether sheep / Watanabe Н., Saito R., Nakano T. [et al.] // PLoS One. – 2014. – Vol.9, № 2. – Р.880-892.
11. А.с. 4411066/14 СССР, МБИ G 01 N33/50. Способ определения желчных кислот в биологических гидкостях / С. П. Весельский, П. С. Лященко, И. А. Лукьяненко (СССР). – № 1624322; Заявл. 25.01.1988; Опубл. 30.01.1991, Бюл. № 4.
12. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency / Setchell K. D., Heubi J. E., Shah S. [et al.] // Gastroenterology. – 2013. – Vol. 144, № 5. – P. 945–955.
13. Clayton P. T. Disorders of bile acid synthesis // J Inherit Metab Dis. – 2011. – Vol. 34, № 3. – P. 593–604.
14. Treatment of bile acid amidation defects with glycocholic acid / Heubi J. E., Setchell K. D., Jha P. // Hepatology. – 2015. – Vol. 61, № 1. – P. 268–274.
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Published
2015-05-27
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Human and Animal Physiology
How to Cite
Serotonin Effects on Conjugation and Hydroxylation of Bile Acid in the Rats Liver. (2015). Notes in Current Biology, 2(302), 124-127. https://doi.org/10.29038/2617-4723-2015-302-124-127
