Longidaza Impact on Artificially Induced Spinal Cord Epidural Fibrosis in Rat

Authors

  • Yakiv Fishcnenko SI “The Institute of Traumatology and Orthopedics” by NAMS of Ukraine
  • Danylo Zavodovskyi Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv
  • Oleksandr Motuziuk Lesya Ukrainka Eastern European National University
  • Tetayna Matvienko Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv
  • Dmytro Nozdrenko Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv
  • Viktoriya Melnichyk Lesya Ukrainka Eastern European National University
  • Olga Dybnik Lesya Ukrainka Eastern European National University

DOI:

https://doi.org/10.29038/2617-4723-2016-332-7-159-164

Keywords:

fibrosis, соеденительная fabric, longidaza

Abstract

Longidaza at dose 1ml/kg impact on artificially induced epidural fibrosis in spinal cord of the wistar rat was investigated. It was shown that administration of chosen concentration of a drug leads to fibrosis structures quantity decrease. Wherein proportion between neural and connective tissue after induction of fibrosis and drug application reduced on 23 % during 5 days and 38 % after 10 days. Maximum fibrosis thickness decline accordingly on 31 % and 43 %. The most significant changes was in decrease of the fibrosis area, up to 56 % after 5 days of the experiment and 78 after 10 days. Results show that longidaza is effectively influences measure of pathological alteration of spinal cord tissues during epidural fibrosis. Due to longidaza administration not only pathologicaly affected area is diminish but also scar tissue itself became less dense and thick. Because of the destructiveness of used fibrosis induction methods in experiment we can suggest that probably it is possible almostly prevent fibrosis using longidaza during minor traumas of spinal cord and surrounding tissues.

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Published

2016-05-23

How to Cite

Fishcnenko, Y., Zavodovskyi, D., Motuziuk, O., Matvienko, T., Nozdrenko, D., Melnichyk, V., & Dybnik, O. (2016). Longidaza Impact on Artificially Induced Spinal Cord Epidural Fibrosis in Rat. Notes in Current Biology, (7(332), 159–164. https://doi.org/10.29038/2617-4723-2016-332-7-159-164